Laboratory Services

Find Assay Testing Forms for New York Blood Center, Rhode Island Blood Center, Innovative Blood Resources/Memorial Blood Centers, Blood Bank of Delmarva and, Community Blood Center of Kansas City.

Comprehensive Laboratory Services and Expert Consultation

We provide specialized laboratory services and expert consultation to hospitals and referral laboratories, addressing both routine and complex patient antibody profiles. Complex cases often require in-depth interpretation, the resolution of challenging scenarios, and access to a well-characterized library of red cells, reagents, and rare blood types essential for patient transfusion needs.

We employ advanced serological techniques and DNA blood group analysis to resolve intricate cases, assess clinical significance, and offer expert guidance in selecting the appropriate blood for transfusion. Our laboratory is home to one of the largest collections of well-characterized red blood cells and sera, which helps identify antibodies and rare blood types. Additionally, we are continuously expanding our inventory by identifying new antigens and novel alleles at the DNA level, providing increasingly personalized options for patients in need.

Licensing and Accreditation

NYBCe’s Immunohematology laboratories hold several critical certifications and accreditations, ensuring the highest standards of service and quality:

• Licensed by the Food and Drug Administration (FDA)
• Approved under Clinical Laboratory Improvement Amendments (CLIA)
• Certified by Delaware, Missouri, Minnesota, Rhode Island, and New York State Departments of Health (DOH)
• Accredited by the Association for the Advancement of Blood & Biotherapies (AABB)
• Partnered with AABB’s American Rare Donor Program, providing an extensive inventory of liquid and frozen blood units to support patients requiring antigen-negative units for transfusion.

Available Testing Services

We offer a wide range of testing services, including:

• Sickle Cell Screening
• Elution and Antigen Phenotyping
• Adsorptions (Autologous and Allogeneic)
• Hemolytic Disease of the Newborn (HDN) Evaluation (Mother and Infant)
• Neutralization with Soluble Blood Group Substances
• Antibody Titration (Including Prenatal and Cold Agglutinin)
• Donath-Landsteiner Test
• Thermal Amplitude Test (30°C Albumin Test)

Our laboratory services are designed to meet the most complex needs in transfusion medicine, offering precise, reliable results that ensure optimal care for patients. Trust NYBCe for your most challenging immunohematology cases, backed by cutting-edge technology and a commitment to excellence.

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Why Partner with NYBCe for Your Genomic Testing Needs?

• Efficient, High-Throughput Testing: Our automated processes enable us to offer genomic testing at a low cost, benefiting from economies of scale.
• Access to Rare Donor Profiles: Our testing increases the identification and accessibility of rare blood type donors.
• Comprehensive National Antigen Profile: We provide the most extensive antigen profiling available in the U.S.
• Expert Staff: Our team is trained in both genetics and immunohematology, ensuring precise interpretation of results with a fast turnaround time.

Standard Genomic Testing

We perform automated genotyping on both donor and patient samples for blood centers, clinics, and hospitals across the country. Our extensive testing goes beyond serological methods, identifying antigens that are otherwise inaccessible, uncovering rare antigen combinations, detecting weak antigens, and identifying rare blood units. DNA testing is available for red cells, platelets, and neutrophil antigens.

We utilize the FDA-approved Immucor PreciseType™ HEA Test Kit, a DNA-based multiplex PCR assay coupled with a robust beadchip microarray for extended blood typing. This method allows us to analyze donor and patient samples efficiently, correlating well with serology results. The test, which processes up to 96 samples at once, analyzes 11 clinically significant blood groups, predicting 358 red blood cell antigens and 3 phenotypic variants in a few hours without requiring confirmatory serology testing.

In addition to multiplex testing, full gene sequencing is available for RhD, RhCE, and other blood group antigen alleles. We also offer PCR-RFLP sequencing to determine ABO genotyping, with the added flexibility to perform the RhD test on non-blood samples such as cheek swabs or other cell types.

PreciseMatch® Blood Products

NYBCe specializes in providing PreciseMatch® blood products nationwide, helping to reduce complications, optimize transfusion compatibility, and enhance the safety of transfusion practices. These antigen-matched blood products are tailored for patients who require precise compatibility with common clinically significant antigens.

PreciseMatch® Blood Products Benefit Patients Who:

• Have warm autoantibodies or are undergoing monoclonal therapy where routine compatibility testing may not be sufficient.
• Face chronic transfusions and are at risk for alloimmunization complications.
• Experience hemolytic reactions or reduced red cell survival after transfusions.
• Have hemoglobinopathies, congenital anemias, bone marrow failure syndromes, or malignancies.

Partner with NYBCe for reliable, high-quality genomic testing and PreciseMatch® blood products to ensure the best possible outcomes for your patients. Our state-of-the-art testing, combined with personalized blood product solutions, enhances transfusion safety and clinical care.

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Our histocompatibility and immunogenetics laboratories provide Human Leukocyte Antigen (HLA) typing for hematopoietic stem cell transplant candidates and their potential donors (related and unrelated), platelet donors and recipients, disease association and drug hypersensitivity, allogeneic cellular therapies, vaccine design, and clinical trials. 

HLA Testing and Methodologies 

• High-resolution Class I and II sequencing for 11 loci – HLA-A, B, C, DRB1, DRB3/4/5, DQA1/DQB1 and DPA1/DPB1 

• Chimerism Testing – Engraftment monitoring of post-transplant samples, quality control testing for detection of cell line contamination 

• Prompt delivery of test results ~5-10 business days from date of sample receipts 

We offer fast and reliable turnaround time for pre-clinical to commercial scale capabilities. Our consultative support on ordering, interpretation of results, and matching strategies is coupled with all our testing services to offer a one-stop solution for all of your HLA testing needs. 

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We offer donor testing for blood centers, hospital blood collection facilities, and stem cell and research programs requiring blood donor screening. Our range of infectious disease testing includes HIV, hepatitis B and C, and CMV for transfusions and research products using highly sensitive nucleic acid amplification testing (NAT). Our specialized testing covers sickle cell disease testing as well as ever-expanding FDA guidance in recent years, comprising Babesia and, West Nile Virus testing. We also offer Chagas and TRALI mitigation services.  

All of our testing lead time typically ensures that blood is ready for transfusion within 24–48 hours post-donation. 

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NYBCe provides platelet antibody screening and cross matching services for patients.

We also provide Platelet Antibody Screen / Cross-Matched Platelets Services for patients.  

We also offer bacterial detection testing and residual white blood cell testing for quality control of leuko-reduced apheresis platelets. 

Our Redi-Kit Sample Shipping Program manages and facilitates patient blood sample transport from hospitals to our Immunohematology, Genomics and HLA Laboratory testing facilities. We provide all the necessary shipping materials and containers along with a hospital username and password to access prepaid FedEx overnight services via an easy-to-use web access point.